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Anti-Mouse CD86 (B7-2) SAFIRE Purified 500 ug

Anti-Mouse CD86 (B7-2) SAFIRE Purified 500 ug

Item no.	08922-25-500
Manufacturer	BioGems
Amount	500 ug
Category	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies
Type	Antibody
Format	SAFIRE Purified
Applications	FC
Clone	PO3.1
Specific against	Human
Host	Rat
Isotype	IgG2b kappa
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The PO3.1 monoclonal antibody specifically reacts with CD86, also known as B7-2, a surface 80 kDa receptor and member of the B7 family. CD86 is a costimulatory molecule, expressed on B and T cells, dendritic cells, astrocytes, macrophages, Langerhans cells, and at a low level in newly explanted B and T lymphocytes. CD86 expression on B lymphocytes is upregulated by B-Cell Receptor complex, CD40 and certain cytokine receptors. CD80 (B7-1) and CD 86 (B7-2) are receptors for CD28 and CTLA-4, on the surface of T lymphocytes, enhancing the interactions between B and T cells.
Research Interest	Innate Immunity
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation	Phosphate-buffered aqueous solution, ph7.2.
References	Hathcock, K. S., Laszlo, G., Dickler, H. B., Bradshaw, J., Linsley, P., & Hodes, R. J. (1993). Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science, 262(5135), 905-907. Inaba, K., Witmer-Pack, M., Inaba, M., Hathcock, K. S., Sakuta, H., Azuma, M., ... & Steinman, R. M. (1994). The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. The Journal of experimental medicine, 180(5), 1849-1860. Hathcock, K. S., Laszlo, G., Pucillo, C., Linsley, P., & Hodes, R. J. (1994). Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. The Journal of experimental medicine, 180(2), 631-640.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 10/25/2024

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