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ARN-21934

ARN-21934

Manufacturer	MedChem Express
Category	Reagents & Chemicals Biochemicals
Type	Biochemicals
Specific against	other
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Item no.	HY-137466-50mg
Targets	Topoisomerase
CASRN	2230854-93-8
eClass 6.1	32160405
eClass 9.0	32160490
Available
Purity	98.08
Product Description	ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etoposide (IC50=120 μM). ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research[1].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	360.46
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 80°C)
Manufacturers Target	Topoisomerase
Isoform	Topo II
Pathway	Cell Cycle/DNA Damage

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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