SAICAR

Item no.	HY-126585-1mg
Manufacturer	MedChem Express
CASRN	3031-95-6
Amount	1 mg
Quantity options	10 mg 1 mg 25 mg 500 ug 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Biochemicals
Specific against	other
Purity	99.36
Formula	C13H19N4O12P
Citations	[1]Keller KE, et al. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. Mol Cell. 2014 Mar 6;53(5):700-9.<br>[2]Keller KE, et al. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. Science. 2012 Nov 23;338(6110):1069-72.
Smiles	O=C(O)C[C@@H](C(O)=O)NC(C1=C(N)N([C@H]2[C@@H]([C@@H]([C@@H](COP(O)(O)=O)O2)O)O)C=N1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	454.28
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 220 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Manufacturers Target	Endogenous Metabolite
Isoform	Human Endogenous Metabolite
Pathway	Metabolic Enzyme/Protease

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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