HSP990

Item no.	B1370-460667
Manufacturer	BOC Sciences
CASRN	934343-74-5
Amount	100mg
Specific against	other
Purity	>98%
Formula	C20H18FN5O2
InCHI	1S/C20H18FN5O2/c1-10-18-16(26-20(22)23-10)9-15(25-19(18)27)12-7-6-11(21)8-13(12)14-4-3-5-17(24-14)28-2/h3-8,15H,9H2,1-2H3,(H,25,27)(H2,22,23,26)/t15-/m1/s1
Smiles	CC1=NC(=NC2=C1C(=O)NC(C2)C3=C(C=C(C=C3)F)C4=NC(=CC=C4)OC)N
Alias	NVP-Hsp990; NVP Hsp990; NVPHsp990; Hsp990; Hsp 990; Hsp-990
Available
Information/Product description	Hsp980 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp980 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses.
Manufacturers Category / Type	Chemicals/Reagents & Chemicals
Product Origin	USA

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