Recombinant Human BAFF Active (OPAE00017)

BAFF (B lymphocyte activating factor) is a member of the tumor necrosis factor (TNF) ligand family which is expressed in T Cells, macrophages, monocytes and dendritic cells. It is also known as BLyS, THANK, TALL, zTNF4 and TNFS20. BAFF enhances B cell survival in vitro and has emerged as a key regulator of peripheric B cell and it is vital homeostatic cytokine for B cells that helps regulate both innate and adaptive immune responses. BAFF binds to three TNF receptors: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium modulator and cyclophilin ligand interactor(TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C).The human BAFF gene code for a 285 amino acids type II transmembrane protein. Recombinant human soluble BAFF is a 151 amino acids containing the TNF-like portion of the extracellular domain of BAFF.

HHHHHHHHHHAVQGPEETVTQDCLQLIADSETPTI QKGSYTFVPWLLSFKRGSALEEKENKILVKETGYF FIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVT LFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAI PRENAQISLDGDVTFFGALKLL

Recombinant human BAFF is lyophilized from 20 mM PBS buffer pH 7 and 0.2 M NaCl.