STAT5B Antibody (OAEC04650)

90 kDa

6777

The protein encoded by this gene is a member of the S TAT family of transcription factors. In response to cytokines and growth factors, S TAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators . This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in divers e biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expres sion. This gene was found to fus e to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dys regulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Purified recombinant fragment of human STAT5B expres sed in E. Coli.