INSR Antibody (Phospho-Tyr1150/IGF1R-Tyr1135) (OAAN02738)

INSR

156 kDa

3643; 3480

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

Polyclonal

A phospho-Serpecific peptide corresponding-Thro residues-Serurrounding-Tyr1150 of human INSR and-Tyr1135 of human IGF1R