Description of target |
Monoclonal rat anti-mouse Erythroid Cells. The TER-119 antigen is a 52 kD glycophorin A-associated protein, also known as Ly-76. TER-119 is an erythroid-specific antigen expressed on early proerythroblasts to mature erythrocytes, but not BFU-E or CFU-E. The TER-119 antibody is useful for distinguishing erythrocytes and cells in the erythroid lineage |
Specificity |
The TER-119 antibody specifically binds to a 52 kDa molecule associated with glycophorin A on cells ofthe erythroid lineage in embryonic yolk sac, fetal liver, newborn liver, adult bone marrow, adult peripheral blood, and adult lymphoid organs. The TER-119 antigen is expressed on erythroid cells from pro-erythroblast through mature erythrocyte stages, but not on cells with BFU-E or CFU-E activities. The TER-119 epitope is not detected on hematopoietic stem cells, lymphoid cells, myeloid cells, or erythroleukemia lines. The TER- 119 mAb is a component of the 'lineage cocktail' used in studies of hematopoietic progenitors to detect, or deplete cells committed to the hematopoietic lineages |