Item no. |
OALA02678 |
Manufacturer |
AVIVA Systems Biology
|
Amount |
50 ug |
Category |
|
Type |
Antibody Polyclonal |
Format |
Liquid |
Applications |
WB, IHC, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG kappa |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
MAP3K1, MAPK/ERK kinase kinase 1, MAPKKK1, MAP/ERK kinase kinase 1, MEK kinase 1, MEKK, MEKK 1, MEKK1, SRXY6 |
Similar products |
MAP3K1, MEKK1, MAPK/ERK kinase kinase 1, MAPKKK1, MEKK, MAP/ERK kinase kinase 1, MEK kinase 1, SRXY6, MEKK 1 |
Available |
|
Description |
MEKK1, a MAP3K type protein kinase, is a member of the stress-activated protein kinase (SAPK) pathways which convey pro-apoptotic signals. The protein consists of a C-terminal protein kinase domain and an extensive N-terminal domain that includes two proline-rich segments containing putative binding sites for proteins with SH3 domains, a consensus binding site for 14-3-3 proteins, two PH domains and an acid rich motif with two sites for cleavage by proapoptotic caspase cysteine proteases. |
Gene symbol |
MAP3K1 |
Alias symbols |
MAP3K1, MAPK/ERK kinase kinase 1, MAPKKK1, MAP/ERK kinase kinase 1, MEK kinase 1, MEKK, MEKK 1, MEKK1, SRXY6 |
Gene_id |
4214 |
Reconstitution and storage |
+4C or -20C, Avoid repeated freezing and thawing. |
Specificity |
Reacts specifically with MEKK1 protein detecting a monomer species migrating at ca.69kD and a trimer species migrating at ca.200kD. Cross-reactivity with other proteins has not been observed. Species cross-reactivity:MEKK1. Tested by Western blotting with HeLa, 293 (kidney) and MEKK1 transfected cells. |
Purification |
Affinity purified |
Warning |
For research use only. |
Immunogen |
MAP3K1 / MEKK1 antibody was raised against recombinant protein encompassed within amino acids 130-300 of the human MEKK1 protein. |
Application Info |
IHC - Paraffin (5 ug/ml), Western blot (1 - 3 ug/ml), ELISA |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.