COX2 Polyclonal Antibody (OABB00222)

Prostaglandin G/H synthase 2

5743

Cyclooxygenase (Cox) is the key enzyme in conversion of arachidonic acid to PGs, and two isoforms, Cox-1 and Cox-2, have been identified.¹ Cox-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine Cox-2 gene in Min mice reduced the incidence of intestinal tumors, suggesting that it is required for tumorigenesis.² This gene is localized to sites associated with retinal blood vessels, and plays an important role in blood vessel formation in the retina.³ And the glucocorticoid receptor suppression of COX-2 is also crucial for curtailing lethal immune activation, and suggest new therapeutic approaches for regulation of T-cell-mediated inflammatory diseases.⁴

Immunogen affinity purified

A synthetic peptide corresponding to a sequence at the N-terminus of human COX2 (26-41aa CQNRGVCMSVGFDQYK), different from the related rat sequence by two amino acids.