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BRCC3 antibody - C-terminal region (ARP61990_P050)

BRCC3 antibody - C-terminal region (ARP61990_P050)

Manufacturer	AVIVA Systems Biology
Category	Oncology Neuroscience Neural Lineage Markers Antibodies Western Blot Immunofluorescence Primary Antibodies By Organ Breast Cancer
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat, Porcine, Rabbit, Guinea Pig, Bovine, Equine
Format	Lyophilized powder
Applications	WB, IF
Amount	100ul
Host	Rabbit
Item no.	ARP61990_P050
eClass 6.1	32160702
eClass 9.0	32160702
Available
Alias	BRCC36, C6.1A, CXorf53, RP11-143H17.2
Gene symbol	BRCC3
Protein name	Lys-63-specific deubiquitinase BRCC36
Protein size	316
Molecular weight	35kDa
Product format	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Gene id	79184
Reconstitution and storage	For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Partner proteins	FAM175B. UBC. FANCG. UIMC1. SUMO1. RABEP2. SMEK1. LARP7. CD2AP. WDHD1. SF3A1. GPHN. HNRNPR. TRIM28. HUWE1. MTA2. SPAG9. CCDC6. HDAC1. NR3C1. FAM175A. SUMO2. PAXIP1. MDC1. BRCA1. GRB2. BABAM1. BRE. BRCC3. COPS5. BACH1. BRCA2. BARD1. USP7. SHMT2. NDUFA10. M
Description of target	This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy.
Homology	Cow: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 86%
Purification	Affinity Purified
Clonality	Polyclonal
Drywet	Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ul

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Delivery expected until 7/26/2024

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