Comparison

Anti-GABA Alpha Receptor, Gamma 2 -Subunit (OAPC00123)

Item no. OAPC00123
Manufacturer AVIVA Systems Biology
Amount 100 ul
Category
Type Antibody Polyclonal
Applications WB
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Chicken (Gallus gallus domesticus), Dog (Canine, Canis lupus familiaris), Cattle (Bovine)
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Available
Manufacturer - Applications
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, human, mouse and non-human primate based on the fact that these species have 100% homology with the amino acid sequence used as antigen.Western blot of 10 ug of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ca.46k gamma 2-subunit of GABAA -R.
Molecular Weight
ca.46kDa
Description
Specific for the ca.46k gamma 2-subunit of the GABAA receptor in Western blots. Prepared from rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.
Gene symbol
GABRG2
Reconstitution and storage
For long term storage -20C is recommended. Stable at -20C for at least 1 year.
Description of target
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alpha s, four beta s and four gamma s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha - and beta -subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma -subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha -subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003).
Purification
Prepared from rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.
Immunogen
Fusion protein from the cytoplasmic loop of the gamma 2-subunit of rat GABAA receptor.
Homology
Rat, Mouse, Human, Bovine, Chicken, Non-human primate, Canine
Manufacturer - Specificity
Specific for the ca.46k gamma 2-subunit of the GABAA receptor in Western blots.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ul
Available: In stock
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