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Anti-Human CD28 - Purified in vivo GOLD™ Functional Grade

Anti-Human CD28 - Purified in vivo GOLD™ Functional Grade

Item no.	LEIN-C2820-1.0mg
Manufacturer	Leinco Technologies
Amount	1 mg
Quantity options	1 mg 100 mg 25 mg 5 mg 50 mg
Category	In Vivo Antibodies In Vivo Antibodies
Type	Antibody Monoclonal
Applications	FC, IP, IHC, IV
Clone	CD28.2
Specific against	Human (Homo sapiens)
Host	Mouse
Purity	> 95% by SDS-PAGE and ≥ 95% monomer by analytical SEC
Citations	1. Stern, LJ. et al. (2005) Proc Natl Acad Sci U S A.102(10):3744-9
NCBI	940
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping condition	Cool pack
Available
Manufacturer - Category	Purified in vivo Functional Grade>Gold Purified Bulk Antibodies\|Primary Monoclonal Antibodies>Immune Checkpoints\|PhenoCycler®\|Primary Monoclonal Antibodies>SurfaceTag Human CD Markers
Manufacturer - Targets	CD28
Country of Origin	USA
Shipping Temperature	Next Day 2-8°C
Storage Conditions	This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Product Description	CD28 is a 44 kD glycoprotein and a member of the Ig superfamily. In its capacity as a costimulatory receptor, CD28 produces co-stimulatory signals necessary for T cell activation and survival. CD28 is the only B7 receptor constitutively expressed on naive T cells. Without having this CD28/B7 interaction, T cells will fail to respond to their specific antigen when coming in contact with an MHC/antigen complex and thus, are said to be anergic.
Background	CD28 is a 44 kD glycoprotein and a member of the Ig superfamily. In its capacity as a costimulatory receptor, CD28 produces co-stimulatory signals necessary for T cell activation and survival. CD28 is the only B7 receptor constitutively expressed on naive T cells. Without having this CD28/B7 interaction, T cells will fail to respond to their specific antigen when coming in contact with an MHC/antigen complex and thus, are said to be anergic.
PubMed	CD28
Ligand/Receptor	CD80, CD86
Manufacturer - Research Area	Costimulatory Molecules
Manufacturer - Specificity	Clone CD28.2 recognizes an epitope on human CD28.
RRID	AB_2829581
Concentration	≥ 2.0 mg/ml
Formulation	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Antigen Distribution	CD28 is expressed on thymocytes, CD4+, CD8+ peripheral T cells, NK cells.
Endotoxin Level	≤ 1.0 EU/mg
Additonal Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-C2820-1.0mg-safety-datasheet.pdf