Background |
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. |
Manufacturers Research Area |
Apoptosis, Apoptosis_Inhibition of Apoptosis, B Cell Receptor Signaling Pathway, Cancer, Cardiovascular, Cell Biology & Developmental Biology, Death Receptor Signaling Pathway, Endocrine & Metabolism, Endocrine and metabolic diseases, Endocrine and metabolic diseases_Obesity, Epigenetics & Nuclear Signaling, IL-6 Receptor Signaling Pathway, Immunology & Inflammation, MAPK-P38 Signaling Pathway, Neurodegenerative Diseases, Neurodegenerative Diseases_Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimers Disease, Neuroscience, NF-kB Signaling Pathway, Protein phosphorylation, Signal Transduction, T Cell Receptor Signaling Pathway, Toll-like Receptor Signaling Pathway, Transcription Factors, |