Alias |
(Ala-IL-8)77,(Ser-IL-8)72,9E3,Beta thromboglobulin like protein,C-X-C motif chemokine 8,CEF-4,chemokine,CXC motif,ligand 8,CXCL8,Emoctakin,GCP-1,GCP/IL-8 protein I,GCP/IL-8 protein II,GCP/IL-8 protein III,GCP/IL-8 protein IV,GCP/IL-8 protein V,GCP/IL-8 protein VI,GCP1,Granulocyte chemotactic protein 1,IL-8,IL-8(1-77),IL-8(9-77),IL8/NAP1 form I,IL8/NAP1 form II,IL8/NAP1 form III,IL8/NAP1 form IV,IL8/NAP1 form V,IL8/NAP1 form VI,IL8,Inteleukin 8,LECT,LUCT,Lymphocyte-derived neutrophil-activating factor,LYNAP,MDNCF,MDNCF-b,MDNCF-c,MONAP,Monocyte-derived neutrophil chemotactic factor,Monocyte-derived neutrophil-activating peptide,NAF,NAP-1,NAP1,Neutrophil activating peptide 1,Neutrophil activating protein 1,Neutrophil-activating factor,Neutrophil-activating protein 1,Protein 3 10C,Protein 3-10C,SCYB8,Small inducible cytokine subfamily B member 8,T cell chemotactic factor,T-cell chemotactic factor,TSG1 |
Background |
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. |