Alias |
hPCl1,MTF2 L2,MTF2L 2,MTF2L2,PCL 1,PCL1,PHD finger protein 1,PHD finger protein1,PHF 1,PHF 2,Phf1,PHF1,PHF2,Plc 1,Plc1,Polycomb like protein 1,Polycomb like protein1,Polycomb-like protein 1,Protein PHF1,T complex testis expressed 3,T complex testis expressed3,Tctex 3,Tctex3 |
Background |
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. |