Alias |
BCIE,BIE,CK 10,CK-10,Cytokeratin-10,EHK,K10,K1C10,Keratin 10,Keratin 10 type I,Keratin,Keratin type i cytoskeletal 10,Keratin type I cytoskeletal 59 kDa,Keratin-10,Keratin10,KPP,KRT10,type I cytoskeletal 10 |
Background |
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. |