Alias |
Anti elastase,EI,ELANH2,Epididymis luminal protein 57,HEL57,ILEU,LEI,Leukocyte elastase inhibitor,M/NEI,MNEI,Monocyte/neutrophil elastase inhibitor,Peptidase inhibitor 2,Pi-2,PI2,Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 1,Serpin B1,Serpin peptidase inhibitor clade B (ovalbumin) member 1,serpinb1 |
Background |
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. |