Alias |
Acid stable subunit of the 140 K IGF complex,Binding protein 29,Binding protein 53,BP 53,BP53,Growth hormone dependent binding protein,IBP 3,IBP-3,IBP3,IBP3,IGF binding protein 3,IGF-binding protein 3,IGFBP 3,IGFBP-3,IGFBP3,Insulin Like Growth Factor Binding Protein 3,Insulin-like growth factor binding protein 3 precursor,Insulin-like growth factor-binding protein 3 |
Background |
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. |