Alias |
DKFZp434E1211,DKFZp434P1672,FLJ10752,FLJ13588,FLJ20388,hVPS35,Maternal embryonic 3,Maternal-embryonic 3,MEM 3,MEM3,PARK17,TCCCTA00141,Vacuolar protein sorting 35 (yeast),Vacuolar protein sorting 35,Vacuolar protein sorting 35 homolog,Vacuolar protein sorting associated protein 35,Vacuolar protein sorting-associated protein 35,Vesicle protein sorting 35,VPS 35,VPS35,VPS35 |
Background |
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. |