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Rabbit anti-SRGAP3 Polyclonal Antibody

Rabbit anti-SRGAP3 Polyclonal Antibody

Item no.	RD78364A-20uL
Manufacturer	Reddot Biotech
Amount	20 uL
Category	Antibodies Primary Antibodies
Type	Antibody Polyclonal
Applications	IHC, ELISA
Specific against	Human, Mouse
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ARHGAP 14,ARHGAP14,Gbi,ME GAP,MEGAP,Mental disorder associated GAP,Mental disorder-associated GAP,Rho GTPase activating protein 14,Rho GTPase-activating protein 14,SLIT ROBO Rho GTPase activating protein 3,SLIT-ROBO Rho GTPase-activating protein 3,srGAP 2,srGAP 3,srGAP2,srGAP3,SRGP 2,SRGP2,SRGP3,WAVE associated Rac GTPase activating protein,WAVE-associated Rac GTPase-activating protein,WRP
Available
Background	SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
Buffer	PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Clonality	Polyclonal
Concentration	0.4mg/mL
Dilution	IHC 1:25-1:100
Immunogen	Recombinant protein of human SRGAP3
Purification_Method	Affinity purification
Storage	Store at -20℃. Avoid repeated freeze / thaw cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 20 uL

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Delivery expected until 9/20/2024

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