Alias |
ASH 2,Ash2 (absent small or homeotic) like,Ash2 (absent,or homeotic) like (Drosophila),ASH2,ASH2 LIKE,ASH2 like protein,ASH2-like protein,Ash2l,ASH2L,ASH2L1>,ASH2L2,Bre 2,Bre2,Discs 2-like,Drosophila absent,small,or homeotic,Drosophila ASH2-like,Set1/Ash2 histone methyltransferase complex subunit ASH2 |
Background |
The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator. Alternative splicing results in a shorter isoform 2, designated ASH2L2, which is missing the first 94 amino acid residues found in ASH2L1. Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif. ASH2L is highly expressed in fetal liver, testis and leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami. |