Alias |
EFN B2,EFNB 2,Efnb2,EFNB2,Eph related receptor tyrosine kinase ligand 5,EPH-related receptor tyrosine kinase ligand 5,ephrin B2,Ephrin-B2,EphrinB2,EPLG 5,EPLG5,Htk L,HTK ligand,HTK-L,HTKL,LERK 5,LERK-5,LERK5,Ligand of eph related kinase 5,MGC126226,MGC126227,MGC126228,OTTMUSP00000024973 |
Background |
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. |