Alias |
Cancer/testis antigen 5.2,Cancer/testis antigen family 5,member 2a,Cancer/testis antigen family 5,member 2b,CT5.2,CT5.2A,CT5.2b,HD21,hom mel 40,HOM-MEL-40,MGC119055,MGC15364,MGC3884,Protein SSX2,RP11-552J9.2,sarcoma,synovial,X-chromosome related 2,SSx,SSX2,SSX2-SYT fusion gene,included,SSX2,SSX2B,Synovial sarcoma,synovial sarcoma X breakpoint 2,Synovial sarcoma,X breakpoint 2B,Tumor antigen HOM-MEL-40,X breakpoint 2 |
Background |
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X; 18)(p11.2; q11.2) translocations that are characteristically found in all synovial sarcomas. |