Alias |
DKFZp434K1210,HD gene regulatory region binding protein 2,HD gene regulatory region-binding protein 2,HD-regulating factor 2,HDBP-2,HDBP2,HDRF-2,Huntington disease gene regulatory region-binding protein 2,Huntington's disease gene regulatory region binding protein 2,Papillomavirus regulatory factor 1,papillomavirus regulatory factor PRF 1,Papillomavirus-binding factor,PBF,PRF-1,PRF1,PTTG1IP,Si-1-8-14,Zinc finger protein 395,ZN395,znf395 |
Background |
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF395 (Zinc finger protein 395), also known as PBF (Papillomavirus-binding factor) and HDBP2 (Huntington disease gene regulatory region-binding protein 2), is a 513 amino acid protein that contains one C2H2-type zinc finger. ZNF395 binds to the 3’-CCGG-5’ sequence within the papillomavirus promoter adjacent to a RUNX1-binding motif. It has also been established that ZNF395 binds to a seven base pair region within the Huntington's disease (HD) gene promoter, an essential element for HD gene expression. ZNF395 is widely expressed and probably shuttles between the nucleus and cytoplasm. |