Alias |
AAC 11,AAC-11,AAC11,Antiapoptosis clone 11 protein,API 5,API-5,api5,API5 like 1,API5,API5L1,Apoptosis inhibitor 5,Cell migration inducing gene 8 protein,Cell migration-inducing gene 8 protein,Fibroblast growth factor 2 interacting factor 2,Fibroblast growth factor 2-interacting factor,FIF,MIG 8,MIG8,Migration inducing protein MIG8,Protein XAGL |
Background |
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |