Alias |
cGMP gated cation channel alpha 1,cGMP-gated cation channel alpha-1,CNCG,CNCG1,CNG 1,CNG channel alpha 1,CNG channel alpha-1,CNG-1,CNG1,Cnga1,CNGA1,Cyclic nucleotide gated cation channel 1,Cyclic nucleotide gated channel alpha 1,Cyclic nucleotide gated channel photoreceptor,Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha-1,Cyclic nucleotide-gated channel,Interleukin 1 homologue,OTTHUMP00000218675,OTTHUMP00000223313,OTTHUMP00000223314,photoreceptor,RCNC1,RCNCa,RCNCalpha,Rod photoreceptor cGMP gated channel subunit alpha,Rod photoreceptor cGMP-gated channel subunit alpha,RP49 |
Background |
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. |