Item no. |
RD75800A-200uL |
Manufacturer |
Reddot Biotech
|
Amount |
200 uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
IHC, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
Conjugate/Tag |
Unconjugated |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
ATP dependent helicase ERCC6 like,ATP-dependent helicase ERCC6-like,DNA excision repair protein ERCC 6 like,DNA excision repair protein ERCC-6-like,ERC6L,ERCC 6L,Ercc6l,Excision repair cross complementing rodent repair deficiency complementation group 6 like,Excision repair protein ERCC6 like,FLJ20105,MGC131695,PICH,Plk1 interacting checkpoint helicase,PLK1-interacting checkpoint helicase,SNF2/RAD54 family protein,Tumor antigen BJ HCC 15,Tumor antigen BJ-HCC-15 |
Available |
|
Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
Format (Type) |
Polyclonal Antibody |
Manufactures Category |
Antibodies |
Background |
PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1, 250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain. |
Concentration |
0.5 mg/mL |
Immunogen |
Recombinant protein of human ERCC6L |
Buffer |
PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method |
Affinity purification |
Dilution |
IHC 1:50-1:200 |
Clonality |
Polyclonal |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.