Alias |
5 HT 2B,5 HT 2B receptor,5 HT(2B),5 HT2B,5 hydroxytryptamine (serotonin) receptor 2B,5 hydroxytryptamine (serotonin) receptor 2B G protein coupled,5 hydroxytryptamine 2B receptor,5 hydroxytryptamine receptor 2B,5-HT-2B,5-HT2B,5-hydroxytryptamine receptor 2B,5HT(2B),5HT2B,5HT2F,Htr 2b,Htr2b,NP75 protein,SEROTONIN 5HT2B RECEPTOR,Serotonin receptor 2B,Stomach fundus serotonin receptor |
Background |
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. |