Item no. |
RD73178A-20uL |
Manufacturer |
Reddot Biotech
|
Amount |
20 uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IF, ELISA, IHC-P |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
DNA ligase IV ATP dependent,DNA joinase,DNA ligase 4,DNA ligase IV,DNA repair enzyme,DNLI4,LIG 4,LIG4,LIG4S,Ligase IV,Ligase IV DNA ATP dependent,Polydeoxyribonucleotide synthase [ATP] 4,Polydeoxyribonucleotide synthase 4,Polydeoxyribonucleotide synthase,Polynucleotide ligase,Sealase |
Available |
|
Background |
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. |
Buffer |
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4. |
Clonality |
Polyclonal |
Concentration |
1mg/mL |
Dilution |
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000 |
Immunogen |
Synthesized peptide derived from the Internal region of human DNA Ligase IV |
Purification_Method |
Affinity purification |
Storage |
Store at -20℃. Avoid repeated freeze / thaw cycles. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.