Alias |
1110051E14Rik,AW212720,EC 2.3.1.48,GCN 5,GCN5 (general control of amino-acid synthesis,yeast,homolog)-like 2,Gcn5,GCN5 general control of amino-acid synthesis 5-like 2 (yeast),GCN5L2,general control of amino acid synthesis 5-like 2,General control of amino acid synthesis protein 5-like 2,General control of amino acid synthesis,yeast,homolog-like 2,HGCN5,Histone acetyltransferase GCN5,Histone acetyltransferase KAT2A,hsGCN5,K(lysine) acetyltransferase 2A,KAT2 A,KAT2A,KAT2A,Lysine acetyltransferase 2A,MGC102791,PCAF-b,STAF97 |
Background |
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner.KAT2A (Lysine Acetyltransferase 2A) is a Protein Coding gene. Diseases associated with KAT2A include Hiv-1. Among its related pathways are Signaling by NOTCH1 and Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is KAT2B. |