Item no. |
PRS-XW-7192-0.05mg |
Manufacturer |
ProSci
|
Amount |
0.05 mg |
Category |
|
Type |
Antibody Primary |
Format |
Liquid |
Applications |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Chicken |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
APT1, FAS1, TNFRSF6, Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, APT1, CD95, APO-1, FASTM, ALPS1A, RP11-399O19.9, FAS (N145) |
Available |
|
Shipping |
blue ice or RT |
By Research Area |
Apoptosis, Neuroscience |
Immunogen |
21-165 |
Applications |
FAS (N-145) antibody can be used for the detection of FAS (N-145) by Western blot, may also work for IHC and ICC. |
Predicted Molecular Weight |
37.7 kDa (calculated) |
Purification |
Antigen affinity-purified |
Clonality |
Polyclonal |
Conjugate |
Unconjugated |
Buffer |
Phosphate-Buffered Saline. No preservatives added. |
Concentration |
1 mg/mL |
Storage Conditions |
FAS antibody can be stored at 4˚ C for short term (weeks). Long term storage should be at -20˚ C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
FAS |
Accession # |
NP_000034.1 |
Protein Gi # |
4507583 |
Ncbi Gene Id # |
355 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
FAS |
Ncbi Official Full Name |
Fas cell surface death receptor |
Ncbi Organism |
Homo sapiens |
Swissprot # |
P25445 |
Background |
Tumor necrosis factor receptor superfamily, member 6 isoform 1; apoptosis antigen 1; Fas antigen; APO-1 cell surface antigen. This protein is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-κ B, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. ** Cat.N |
Background References 1 |
Brunner, T. et al : Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373: 441-444, 1995. |
1st Image Caption |
Western Blot: XW-7192 dilution: 1:2, 000, Goat anti-HRP dilution: 1:1, 000. E coli-derived fusion protein as test antigen. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.