CD81 Antibody [2F7] (PE)

blue ice or RT

Mouse epithelial cell line PAM212

CD81

[2F7]

PE

0.1 mg/mL

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Cd81

12520

Cd81

Mus musculus

CD81, also known as TAPA-1, is an integral membrane protein expressed on a variety of cell types and has a high degree of sequence homology between human and mouse. CD81 is expressed on thymic stromal cells where it plays an important role in the transition of gammadelta+ T cells to more mature T cells with alphabeta T cell receptors. Immunohistochemical staining has revealed that its expression is localized to the subcapsular region of the thymus and, specifically, on cells that have distinct clustering patterns. It has been speculated that the ligand for CD81 is the pre-T cell receptor which is composed of a TCR beta chain and glycoprotein pTalpha. The monoclonal antibody 2F7 can block thymocyte interaction with CD81 in vitro.