« Back
Home /
p53 (Ab 46) Antibody

p53 (Ab 46) Antibody

Item no.	PRS-79-534-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Oncology Antibodies Western Blot Primary Antibodies By Organ Lung Cancer Bladder Cancer Breast Cancer
Type	Antibody Primary
Format	Liquid
Applications	WB
Specific against	Human
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	P53, BCC7, LFS1, TRP53, CD49D, Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13
Available
Shipping	blue ice or RT
By Research Area	Apoptosis, Cancer, Cell Cycle
Immunogen	p53 (Ab-46) antibody was raised against a peptide sequence around aa. 44~48 (M-L-S-P-D) derived from Human p53.
Applications	Western Blot: 1:500~1:1000
Specificity	This antibody detects endogenous level of total p53 protein.
Predicted Molecular Weight	53 kDa
Purification	Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality	Polyclonal
Conjugate	Unconjugated
Buffer	Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	1 mg/mL
Storage Conditions	Store antibody at -20˚ C for up to one year.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	TP53
Accession #	NP_000537.3
Protein Gi #	120407068
Ncbi Gene Id #	7157
Ncbi Official Symbol	TP53
Ncbi Official Full Name	tumor protein p53
Ncbi Organism	Homo sapiens
Swissprot #	P04637
Background	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.
Background References 1	Dhavan, R. and Tsai, L. H. (2001) Nat Rev Mol Cell Biol. 2: 749-759. Patrick, G. N. et al. (1998) J Biol Chem. 273: 24057-24064. Di Stefano V, et al. (2005) Oncogene. 24 (35): 5431-5442. Mayo LD, et al. (2005) J Biol Chem. 280 (28): 25953-25959. Wang L, et al. (2005) Oncogene. 24 (18): 3020-3027.
1st Image Caption	Western blot analysis of lysed extracts from HT29 cells using p53 (Ab-46).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.1 mg

available

Delivery expected until 9/6/2024