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SHP 2 (Ab 580) Antibody

SHP 2 (Ab 580) Antibody

Item no.	PRS-79-415-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Type	Antibody Primary
Format	Liquid
Applications	WB, IF, IHC
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, CDX3, Protein-tyrosine phosphatase 2C
Available
Shipping	blue ice or RT
By Research Area	Other
Immunogen	SHP-2 (Ab-580) antibody was raised against a peptide sequence around aa.578~582 (R-V-Y-E-N) derived from Human SHP-2.
Applications	Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Specificity	This antibody detects endogenous level of total SHP-2 protein.
Predicted Molecular Weight	72 kDa
Purification	Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality	Polyclonal
Conjugate	Unconjugated
Buffer	Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	1 mg/mL
Storage Conditions	Store antibody at -20˚ C for up to one year.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	PTPN11
Accession #	NP_002825.3
Protein Gi #	33356177
Ncbi Gene Id #	5781
Ncbi Official Symbol	PTPN11
Ncbi Official Full Name	protein tyrosine phosphatase, non-receptor type 11
Ncbi Organism	Homo sapiens
Swissprot #	Q06124
Background	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
Background References 1	Ferjoux G, et al. (2003) Mol Biol Cell. 2003; 14 (9): 3911-3928. Shi ZQ, et al. (2000) Mol Cell Biol ; 20 (5): 1526-1536. Li C, Friedman JM. (1999) Proc Natl Acad Sci U S A ; 96 (17): 9677-9682Manes S, et al. (1999) Mol Cell Biol ; 19 (4): 3125-3135. Oh ES, et al. (1999) Mol Cell Biol; 19 (4): 3205-3215.
1st Image Caption	Western blot analysis of lysed extracts from 293 cells using SHP-2 (Ab-580).
2nd Image Caption	Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SHP-2 (Ab-580).Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using SHP-2 (Ab-580).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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