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p62Dok (Ab 398) Antibody

p62Dok (Ab 398) Antibody

Item no.	PRS-79-393-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Oncology Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies By Organ Colorectal Cancer
Type	Antibody Primary
Format	Liquid
Applications	WB, IF, IHC
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	P62DOK, CK2A1, DOK1
Available
Shipping	blue ice or RT
By Research Area	Other
Immunogen	p62Dok (Ab-398) antibody was raised against a peptide sequence around aa.396~400 (P-I-Y-D-E) derived from Human p62Dok.
Applications	Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Specificity	This antibody detects endogenous level of total p62Dok protein.
Predicted Molecular Weight	62 kDa
Purification	Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality	Polyclonal
Conjugate	Unconjugated
Buffer	Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	1 mg/mL
Storage Conditions	Store antibody at -20˚ C for up to one year.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	DOK1
Accession #	NP_001372.1
Protein Gi #	4503357
Ncbi Gene Id #	1796
Ncbi Official Symbol	DOK1
Ncbi Official Full Name	docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Ncbi Organism	Homo sapiens
Swissprot #	Q99704
Background	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Background References 1	Michael J. Wick, et, al. (2001) J. Biol. Chem; 276: 42843 - 42850. Paul D. Simoncic, et, al. (2006) Mol. Cell. Biol; 26: 4149 - 4160. Nadia Dube, et, al. (2004) PNAS; 101: 1834. Adam C. Yopp, et al. (2005) J. Immunol; 175: 2913 - 2924.
1st Image Caption	Western blot analysis of lysed extracts from K562, HL-60 and JK cells using p62Dok (Ab-398).
2nd Image Caption	Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p62Dok (Ab-398).Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using p62Dok (Ab-398).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/6/2024