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CD178 Antibody [NOK-1] (APC)

CD178 Antibody [NOK-1] (APC)

Item no.	PRS-76-939-100tests
Manufacturer	ProSci
Amount	100 tests
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies Cell Biology Cell Status Apoptosis Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	liquid
Applications	FC
Specific against	Human
Host	Mouse
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	APTL, FASL, CD178, CD95L, ALPS1B, CD95-L, TNFSF6, APT1LG1, FASLG
Available
Shipping	blue ice or RT
By Research Area	Apoptosis, Cancer
Specificity	The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand.
Purification	The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality	Monoclonal
Clone	NOK-1
Isotype	Mouse IgG1, kappa
Conjugate	APC
Buffer	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration	batch dependent
Storage Conditions	The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	FASLG
Ncbi Gene Id #	356
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	FASLG
Ncbi Official Full Name	Fas ligand (TNF superfamily, member 6)
Ncbi Organism	Homo sapiens
Swissprot #	P48023
Background	The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand. CD178 is a TNF superfamily type II transmembrane glycoprotein expressed by activated T and NK cells and is involved in Fas-mediated apoptosis of lymphocytes. CD178 is also expressed by monocytes, neutrophils, granulocytes and the parenchymal cells of the retina and cornea. The NOK-1 antibody has been reported to bind to COOH-terminus of the Fas ligand in the region associated with Fas binding.
Background References 1	Stber, E., Neurath, M., Calderhead, D., Perry Fell, H., Strober, W. (1995). Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells.Immunity, 2(5), 507-521.
Background References 2	Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., ... Okumura, K. (1999). CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells.The Journal of Immunology, 162(12), 7058-7066.
Background References 3	Calderhead, D. M., Buhlmann, J. E., Van den Eertwegh, A. J., Claassen, E., Noelle, R. J., Fell, H. P. (1993). Cloning of mouse Ox40: a T cell activation marker that may mediate TB cell interactions.The Journal of Immunology, 151(10), 5261-5271.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 tests

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Delivery expected until 9/6/2024

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