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CD127 Antibody [RDR5] (PE-Cy5)

CD127 Antibody [RDR5] (PE-Cy5)

Item no.	PRS-76-928-25tests
Manufacturer	ProSci
Amount	25 tests
Category	Oncology Antibodies By Cell Type Hematology Leukemia Lymphoma Flow Cytometry Primary Antibodies By Organ Lung Cancer
Type	Antibody Monoclonal
Format	liquid
Applications	FC
Specific against	Human
Host	Mouse
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	ILRA, CD127, IL7RA, CDW127, IL-7R-alpha, IL7R
Available
Shipping	blue ice or RT
By Research Area	Chemokines & Cytokines, Growth Factors
Specificity	The RDR5 monoclonal antibody specifically reacts with human CD127, a 60-90 kDA type I transmembrane glycoprotein also known as the IL-7 receptor alpha chain.
Purification	The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality	Monoclonal
Clone	RDR5
Isotype	Mouse IgG1, kappa
Conjugate	PE-Cy5
Buffer	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration	batch dependent
Storage Conditions	The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	IL7R
Ncbi Gene Id #	3575
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	IL7R
Ncbi Official Full Name	interleukin 7 receptor
Ncbi Organism	Homo sapiens
Swissprot #	P16871
Background	The RDR5 monoclonal antibody specifically reacts with human CD127, a 60-90 kDA type I transmembrane glycoprotein also known as the IL-7 receptor alpha chain. CD127 binds with CD132 (gamma c) to forms the IL-7 receptor that is expressed on mature T cells and immature B cells. Since CD127 expression is downregulated in Treg cells, it can be used as a marker for differentiating them from common T cells. The binding of the RDR5 antibody can be blocked by pre-incubating the cells with human IL-7.
Background References 1	Sallusto, F., Lenig, D., Frster, R., Lipp, M., Lanzavecchia, A. (1999). Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.Nature, 401(6754), 708-712.
Background References 2	Yoshida, R., Nagira, M., Imai, T., Baba, M., Takagi, S., Tabira, Y., ... Yoshie, O. (1998). EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC.International immunology, 10(7), 901-910.
Background References 3	Lee, N., Llano, M., Carretero, M., Ishitani, A., Navarro, F., Lpez-Botet, M., Geraghty, D. E. (1998). HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A.Proceedings of the National Academy of Sciences, 95(9), 5199-5204.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 tests

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Delivery expected until 9/6/2024