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CD161 Antibody [HP-3G10] (FITC)

CD161 Antibody [HP-3G10] (FITC)

Item no.	PRS-76-834-100tests
Manufacturer	ProSci
Amount	100 tests
Category	Neuroscience Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	liquid
Applications	FC
Specific against	Human
Host	Mouse
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	NKR, CD161, CLEC5B, NKR-P1, NKRP1A, NKR-P1A, hNKR-P1A, KLRB1
Available
Shipping	blue ice or RT
By Research Area	Innate Immunity, Immunology
Specificity	The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A.
Purification	The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality	Monoclonal
Clone	HP-3G10
Isotype	Mouse IgG1, kappa
Conjugate	FITC
Buffer	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration	batch dependent
Storage Conditions	The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	KLRB1
Ncbi Gene Id #	3820
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	KLRB1
Ncbi Official Full Name	killer cell lectin-like receptor subfamily B, member 1
Ncbi Organism	Homo sapiens
Swissprot #	Q12918
Background	The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A. CD161 is expressed on most natural killer cells, subsets of CD4+ and CD8+ T lymphocytes, gammadelta TCR T lymphocytes, a subset of CD3+ thymocytes, and especially on CD45RO+ T lymphocytes. Reports indicate that it may serve as a specific receptor for some natural killer cell targets and a possible stimulatory role.
Background References 1	Mrquez, C., Trigueros, C., Franco, J. M., Ramiro, A. R., Carrasco, Y. R., Lpez-Botet, M., Toribio, M. L. (1998). Identification of a common developmental pathway for thymic natural killer cells and dendritic cells.Blood, 91(8), 2760-2771.
Background References 2	Cosmi, L., De Palma, R., Santarlasci, V., Maggi, L., Capone, M., Frosali, F., ... Annunziato, F. (2008). Human interleukin 17producing cells originate from a CD161+ CD4+ T cell precursor.The Journal of experimental medicine, 205(8), 1903-1916.
Background References 3	Exley, M., Porcelli, S., Furman, M., Garcia, J., Balk, S. (1998). CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant Valpha 24Jalpha Q T cell receptor alpha chains.The Journal of experimental medicine, 188(5), 867-876.
1st Image Caption	Human peripheral blood lymphocytes were stained with FITC HP-3G10 with relevant isotype control in Red.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Delivery expected until 9/6/2024

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