Item no. |
PRS-76-792-100tests |
Manufacturer |
ProSci
|
Amount |
100 tests |
Category |
|
Type |
Antibody Monoclonal |
Format |
liquid |
Applications |
FC |
Specific against |
Human |
Host |
Mouse |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
CD29, FNRB, MDF2, VLAB, GPIIA, MSK12, VLA-BETA, ITGB1 |
Available |
|
Shipping |
blue ice or RT |
By Research Area |
Cancer |
Specificity |
The TS2/16 moncolonal antibody specifically reacts with human CD29 (Integrin beta1), a 130 kDA type I glycoprotein expressed on hematopoietic and non-hematopoietic cells. |
Purification |
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
Clonality |
Monoclonal |
Clone |
TS2/16 |
Isotype |
Mouse IgG1, kappa |
Conjugate |
PE |
Buffer |
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
Concentration |
batch dependent |
Storage Conditions |
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
ITGB1 |
Ncbi Gene Id # |
3688 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
ITGB1 |
Ncbi Official Full Name |
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
Ncbi Organism |
Homo sapiens |
Swissprot # |
P05556 |
Background |
The TS2/16 moncolonal antibody specifically reacts with human CD29 (Integrin beta1), a 130 kDA type I glycoprotein expressed on hematopoietic and non-hematopoietic cells. It forms the VLA-(1-6) molecules with integrin alpha-(1-6) and is involved in the adhesion between cell-cell and cell-matrix. The TS2/16 antibody has been found to activate beta 1 integrins. |
Background References 1 |
Ridger, V. C., Wagner, B. E., Wallace, W. A., Hellewell, P. G. (2001). Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation.The Journal of Immunology, 166(5), 3484-3490. |
Background References 2 |
Noto, K., Kato, K., Okumura, K., Yagita, H. (1995). Identification and functional characterization of mouse CD29 with a mAb.International immunology, 7(5), 835-842. |
Background References 3 |
Sangaletti, S., Di Carlo, E., Gariboldi, S., Miotti, S., Cappetti, B., Parenza, M., ... Colombo, M. P. (2008). Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis.Cancer research, 68(21), 9050-9059. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.