CD8a Antibody [OKT8] (Violet-450)

blue ice or RT

The OKT8 monoclonal antibody specifically reacts with human CD8alpha molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa.

Monoclonal

MouseIgG2a

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

None

925

CD8A

Homo sapiens

The OKT8 monoclonal antibody specifically reacts with human CD8alpha molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa. CD8alpha is a member of the Ig superfamily, expressed as a homodimer (CD8alphaalpha) or as a heterodimer (CD8alphabeta). CD8+ alphabeta T lymphocytes express both CD8alphaalpha and CD8alphabeta, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes.OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

Thomas, Y., Sosman, J., Irigoyen, O., Friedman, S. M., Kung, P. C., Goldstein, G., Chess, L. (1980). Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative TT interactions in the immunoregulation of B cell differentiation.The Journal of Immunology, 125(6), 2402-2408.