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CD70 Antibody [FR70]

CD70 Antibody [FR70]

Item no.	PRS-76-031-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	liquid
Applications	FC
Specific against	Mouse
Host	Rat
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Cd27l, CD27LG, Tnfsf7, Cd70
Available
Shipping	blue ice or RT
By Research Area	Immunology, Functional Assays
Specificity	The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily.
Purification	The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality	Monoclonal
Clone	FR70
Isotype	Rat IgG2b, kappa
Conjugate	Unconjugated
Buffer	Phosphate-buffered aqueous solution, ph7.2.
Concentration	batch dependent
Storage Conditions	The product should be stored undiluted at 4˚ C . Do not freeze.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	Cd70
Ncbi Gene Id #	21948
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	Cd70
Ncbi Official Full Name	CD70 antigen
Ncbi Organism	Mus musculus
Swissprot #	O55237
Background	The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.
Background References 1	Tesselaar, K., Gravestein, L. A., Van Schijndel, G. M., Borst, J., Van Lier, R. A. (1997). Characterization of murine CD70, the ligand of the TNF receptor family member CD27.The Journal of Immunology, 159(10), 4959-4965.
Background References 2	Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., ... Okumura, K. (1998). Characterization of murine CD70 by molecular cloning and mAb.International immunology, 10(4), 517-526.
Background References 3	Bullock, T. N., Yagita, H. (2005). Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.The Journal of Immunology, 174(2), 710-717.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/6/2024

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