SHROOM3 Antibody

blue ice or RT

Rabbit polyclonal SHROOM3 antibody was raised against an 18 amino acid peptide near the center of human SHROOM3.

The immunogen is located within amino acids 850 - 900 of SHROOM3.

SHROOM3 antibody is human specific. At least four isoforms of SHROOM3 are known to exist; this antibody will detect all four isoforms. SHROOM3 antibody is predicted to not cross-react with other SHROOM family members.

220 kDa

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 7117P – SHROOM3 Peptide

None

NP_065910

57619

SHROOM3

homo sapiens

SHROOM3 Antibody: SHROOM family members play diverse roles in the development of the nervous system and other tissues. SHROOM3 is an actin-binding protein is a regulator of the microtubule cytoskeleton during epithelial morphogenesis and is sufficient and necessary to induce a redistribution of the microtubule regulator gamma-tubulin. It is necessary for both apiscobasal cell elongation and apical constriction in the neural epithelium. SHROOM3 has also been shown to be essential for cell shape changes and morphogenesis in the developing vertebrate gut, with its transcription relying on the Pitx1 transcription factor.

Lee C, Scherr HM, and Wallingford JB. Shroom family proteins regulate gamma-tubulin distribution and microtubule architecture during epithelial cell shape change. Development 2007; 134:1431-41.

Chung MI, Nascone-Yoder NM, Grover SA, et al. Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut. Development 2010; 137:1339-49.