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GDF1 Antibody

GDF1 Antibody

Item no.	PRS-7093-0.02mg
Manufacturer	ProSci
Amount	0.02 mg
Category	Antibodies Western Blot ELISA Immunofluorescence Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, ELISA
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GDF1 Antibody: RAI, DORV, DTGA3GDF-1
Available
Shipping	blue ice or RT
By Research Area	Stem Cell
Immunogen	Rabbit polyclonal GDF1 antibody was raised against a 16 amino acid peptide near the amino terminus of human GDF1. The immunogen is located within amino acids 30 - 80 of GDF1.
Applications	GDF1 antibody can be used for detection of GDF1 by Western blot at 1 - 2 μ g/mL. For immunofluorescence start at 20 μ g/mL. Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity	GDF1 antibody is predicted to not cross-react with any other members of the growth differentiation factor family.
Positive Control 1	Cat. No. 1462 - Rat Lung Tissue Lysate
Positive Control 2	Cat. No. 10-101 - Human Lung Tissue Slide
Predicted Molecular Weight	41 kDa
Purification	GDF1 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	GDF1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	GDF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 7093P – GDF1 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	GDF1
Accession #	NP_001483
Protein Gi #	110349792
Ncbi Gene Id #	2657
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	GDF1
Ncbi Official Full Name	growth differentiation factor 1
Ncbi Organism	homo sapiens
Swissprot #	P27539
Background	GDF1 Antibody: Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. GDF1 was initially identified as a temporally expressed gene in the mouse central nervous system during embryonic development, with only one isoform detected in adult tissues. GDF1 is required for left-right patterning during development and directly interacts with Nodal, another member of the TGF-beta superfamily. It has been suggested that GDF1 regulates the activity and signaling range of Nodal through direct interaction.
Background References 1	Massague J. 1990. The transforming growth factor-beta family. Ann. Rev. Cell Biol. 6:597-641.
Background References 2	Lee SJ. Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure. Proc. Natl. Acad. Sci. USA 1991; 88:4250-4.
Background References 3	Rankin CT, Bunton T, Lawler AM, et al. Regulation of left-right patterning in mice by growth/differentiation factor-1. Nat. Genet. 2000; 24:262-5.
Background References 4	Tanaka C, Sakuma R, Nakamura T, et al. Long-range action of Nodal requires interaction with GDF1. Genes Dev. 2007; 21:3272-82.
1st Image Caption	Western blot analysis of GDF1 in rat lung tissue lysate with GDF1 antibody at (A) 1 and (B) 2 μ g/mL.
3rd Image Caption	Immunofluorescence of GDF1 in human lung tissue with GDF1 antibody at 20 μ g/mL.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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