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TET3 Antibody

TET3 Antibody

Item no.	PRS-7013-0.02mg
Manufacturer	ProSci
Amount	0.02 mg
Category	Oncology Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Testicular & Prostate Cancer
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, ELISA, IHC-P
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	TET3 Antibody: hCG_40738, KIAA0401, Methylcytosine dioxygenase TET3
Available
Shipping	blue ice or RT
By Research Area	Stem Cell
Immunogen	TET3 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human TET3. The immunogen is located within amino acids 1520 - 1570 of TET3.
Applications	TET3 antibody can be used for detection of TET3 by Western blot at 1 μ g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ g/mL. For immunofluorescence start at 20 μ g/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity	At least three isoforms of TET3 are known to exist. TET3 antibody is predicted to not cross react with other TET proteins.
Positive Control 1	Cat. No. 1220 - SK-N-SH Cell Lysate
Positive Control 2	Cat. No. 10-301 - Human Brain Tissue Slide
Predicted Molecular Weight	183 kDa
Purification	TET3 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	TET3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	TET3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 7013P – TET3 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	TET3
Accession #	NP_001274420
Protein Gi #	149944516
Ncbi Gene Id #	200424
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	TET3
Ncbi Official Full Name	TET methylcytosine dioxygenase 3
Ncbi Organism	homo sapiens
Swissprot #	O43151
Background	TET3 Antibody: TET3, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine and is most abundantly expressed in hematopoietic cells. Unlike the related TET2 protein, mutations in TET3 have not been observed in any myeloid malignancies. TET3 has been shown to be involved in the demethylation of zygotic DNA before the first mitosis and has been suggested to be involved in the epigenetic reprogramming of the zygotic paternal DNA following natural fertilization and may also contribute to somatic cell nuclear reprogramming during animal cloning.
Background References 1	Langemeijer SM, Kuiper RP, Berends M, et al. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat. Genet. 2009; 41:838-42.
Background References 2	Schaub FX, Looser R, Li S, et al. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood 2011; 115:2003-7.
Background References 3	Langemeijer SMC, Aslanyan MG, and Jansen JH. TET proteins in malignant hematopoiesis. Cell Cycle 2009; 4044-8.
Background References 4	Gu TP, Guo F, Yang H, et al. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 2011; 477:606-10.
1st Image Caption	Western blot analysis of TET3 in SK-N-SH cell lysate with TET3 antibody at 1 μ g/ml in (A) the absence and (B) the presence of blocking peptide.
2nd Image Caption	Immunohistochemistry of TET3 in human brain tissue with TET3 antibody at 2.5 μ g/ml.
3rd Image Caption	Immunofluorescence of TET3 in human brain tissue with TET3 antibody at 20 μ g/mL.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Delivery expected until 10/4/2024

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