« Back
Home /
CLEC2A Antibody

CLEC2A Antibody

Item no.	PRS-6959-0.02mg
Manufacturer	ProSci
Amount	0.02 mg
Category	Neuroscience Aging & Neurological Disorders Antibodies Western Blot ELISA Immunofluorescence Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, ELISA
Specific against	Human
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CLEC2A Antibody: KACL, PILAR, UNQ5792, KACL, UNQ5792/PRO19597, C-type lectin domain family 2 member A, Keratinocyte-associated C-type lectin
Available
Shipping	blue ice or RT
By Research Area	Immunology
Immunogen	CLEC2A antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CLEC2A. The immunogen is located within the first 50 amino acids of CLEC2A.
Applications	CLEC2A antibody can be used for detection of CLEC2A by Western blot at 1 μ g/mL. For immunofluorescence start at 20 μ g/mL. Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity	CLEC2A antibody is human specific. Two alternatively spliced transcript variants have been observed.
Positive Control 1	Cat. No. 1204 - K562 Cell Lysate
Positive Control 2	Cat. No. 17-004 - K-562 Cell Slide
Purification	CLEC2A Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	CLEC2A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	CLEC2A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 6959P – CLEC2A Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	CLEC2A
Accession #	NP_001124183
Protein Gi #	195222725
Ncbi Gene Id #	387836
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	CLEC2A
Ncbi Official Full Name	C-type lectin domain family 2, member A
Ncbi Organism	Homo sapiens
Swissprot #	Q6UVW9
Background	CLEC2A Antibody: CLEC2A (C-type lectin domain family 2 member A), also known as PILAR (proliferation-induced lymphocyte-associated receptor) is involved in modulating T-cell expansion. It is a 32 kDa single-pass type II membrane protein that contains one C-type lectin domain in its extracellular region and belongs to the CTL/CTLD superfamily. CLEC2A is mainly expressed in skin and highly expressed in CD8(+), B lymphocytes and naive CD4(+) T cells. Manipulation of CLEC2A signaling may be important for treatment of autoimmune diseases and cancer.
Background References 1	Huarte E, Cubillos-Ruiz JR, Nesbeth YC, et al. PILAR is a novel modulator of human T-cell expansion. Blood 2008; 112:1259-68.
Background References 2	Drickamer K. C-type lectin-like domains. Curr. Opin. Struct. Biol. 1999; 9:585-90
Background References 3	Spreu J, Kienle EC, Schrage B, et al. CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL-CD69-LLT1 family. Immunogenetics 2007; 59:903-12.
Background References 4	Spreu J, Kuttruff S, Stejfova V, et al. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Proc. Natl. Acad. Sci. USA 2010; 107:5100-5.
1st Image Caption	Western blot analysis of CLEC2A in K562 cell lysate with CLEC2A antibody at 1 μ g/ml in (A) the absence and (B) the presence of blocking peptide.
3rd Image Caption	Immunofluorescence of CLEC2A in K562 cells with CLEC2A antibody at 20 μ g/mL.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.02 mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 10 days

Compare

Add to wishlist

Recommend by mail