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LINGO1 Antibody

LINGO1 Antibody

Item no.	PRS-62-793-400ul
Manufacturer	ProSci
Amount	400 ul
Category	Oncology Metabolism Glucose Homeostasis Antibodies By Cell Type Carcinoma Cell Biology Cell Status Necrosis Apoptosis Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IHC-P
Specific against	Human
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat and immunoglobulin domain-containing protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, LINGO1,
Available
Shipping	blue ice or RT
By Research Area	Cell Cycle, Neuroscience
Homology	Predicted species reactivity based on immunogen sequence: Chicken, Monkey, Mouse
Immunogen	This LINGO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-92 amino acids from the N-terminal region of human LINGO1.
Applications	For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight	70 kDa
Purification	This antibody is purified through a protein G column, followed by dialysis against PBS.
Clonality	Polyclonal
Isotype	Rabbit Ig
Conjugate	Unconjugated
Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration	batch dependent
Storage Conditions	Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	LINGO1
Accession #	Q96FE5
Protein Gi #	74760819
Ncbi Gene Id #	84894
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	LINGO1
Ncbi Official Full Name	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Ncbi Organism	Homo sapiens
Swissprot #	Q96FE5
Background	LINGO1 is a functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. It is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.
Background References 1	Inoue, H., Proc. Natl. Acad. Sci. U.S.A. 104 (36), 14430-14435 (2007)
Background References 2	Satoh, J., Neuropathol. Appl. Neurobiol. 33 (1), 99-107 (2007)
Background References 3	Mosyak, L., J. Biol. Chem. 281 (47), 36378-36390 (2006)
Background References 4	Mi, S., Nat. Neurosci.(3), 221-228 (2004)
1st Image Caption	Western blot analysis of LINGO1 using rabbit polyclonal LINGO1 Antibody.293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LINGO1 gene (Lane 2).
2nd Image Caption	Formalin-fixed and paraffin-embedded human brain tissue reacted with LINGO1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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