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UBE4B Antibody

UBE4B Antibody

Item no.	PRS-61-075-400ul
Manufacturer	ProSci
Amount	400 ul
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IHC-P
Specific against	Human, Mouse
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ubiquitin conjugation factor E4 B, 632-, UBE4B (<a href="http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12500" target="_blank">HGNC:12500</a>)
Available
Shipping	blue ice or RT
Immunogen	This UBE4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-142 amino acids from the N-terminal region of human UBE4B.
Applications	For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100
Predicted Molecular Weight	146 kDa
Purification	This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Clonality	Polyclonal
Isotype	Rabbit Ig
Conjugate	Unconjugated
Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration	batch dependent
Storage Conditions	Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	UBE4B
Accession #	O95155
Ncbi Gene Id #	10277
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	UBE4B
Ncbi Official Full Name	Ubiquitin conjugation factor E4 B
Ncbi Organism	Homo sapiens
Swissprot #	O95155
Background	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE4B represents an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. UBE4B also the strongest candidate among the neuroblastoma tumor suppressors.
Background References 1	Ishikawa, K., et al., DNA Res. 5(3):169-176 (1998).
Background References 2	Mahoney, J.A., et al., Biochem. J. 361 (Pt 3), 587-595 (2002).
1st Image Caption	Antibody is used in Western blot to detect UBE4B in mouse kidney tissue lysate.
2nd Image Caption	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 9/6/2024

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