WDR35 Antibody

blue ice or RT

Predicted species reactivity based on immunogen sequence: Rat: (94%), Mouse: (94%)

WDR35 antibody can be used for detection of WDR35 by immunohistochemistry at 5 μ g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Cat. No. 11-701 - Human Testis Tissue Slide

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 5867P – WDR35 Peptide

None

NP_001006658

57539

WDR35

Homo sapiens

WDR35 Antibody: WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR35, also known as CED2, has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED), an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.

Mill P, Lockhart PJ, Fitzpatrick E, et al. Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis. Am J. Hum. Genet. 2011; 88:508-15.