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CDKN1B Antibody

CDKN1B Antibody

Item no.	PRS-56-976-400ul
Manufacturer	ProSci
Amount	400 ul
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot Senescence Primary Antibodies By Organ Lung Cancer
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IHC-P
Specific against	Human
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1
Available
Shipping	blue ice or RT
By Research Area	Cancer, Cell Cycle
Immunogen	This CDKN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the C-terminal region of human CDKN1B.
Applications	For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight	22 kDa
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality	Polyclonal
Isotype	Rabbit Ig
Conjugate	Unconjugated
Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration	batch dependent
Storage Conditions	Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	CDKN1B
Accession #	P46527
Ncbi Gene Id #	1027
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	CDKN1B
Ncbi Official Full Name	Cyclin-dependent kinase inhibitor 1B
Ncbi Organism	Homo sapiens
Swissprot #	P46527
Background	This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].
Background References 1	Kajihara, R., et al. Biochem. Biophys. Res. Commun. 401(3):350-355(2010) Kedde, M., et al. Nat. Cell Biol. 12(10):1014-1020(2010) Canbay, E., et al. Anticancer Res. 30(7):3093-3098(2010) Do Nascimento Borges, B., et al. In Vivo 24(4):579-582(2010) Qin, J., et al. Hepatogastroenterology 57 (99-100), 547-553 (2010) :
1st Image Caption	Western blot analysis in human normal Uterus tissue lysates (35ug/lane).
2nd Image Caption	CDKN1B Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 10/4/2024

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